ABSTRACT
Curcumin, which is extracted from the plant Curcuma longa, has been used in the therapeutic arsenal for clinical oncology. Curcumin has chemopreventive and antitumoral activities against some aggressive and recurrent cancers. The expressions and activities of various proteins, such as inflammatory cytokines and enzymes, transcription factors, and gene-products linked with cell survivals and proliferation, can be modified by curcumin. Moreover, curcumin decreases the toxic effect of mitomycin C. Though curcumin has shown highly cytotoxic to some cancer cell lines, curcumin is insoluble and instable in water. The solubility of curcumin could be enhanced by utilizing the solubilizing properties of rubusoside. In addition, the selective delivery of synthetic analogs or nanotechnology-based formulations of curcumin to tumors may improve the chemopreventive and chemotherapeutic effects. The focus of this short review is to describe how curcumin participates in antitumor processes in breast cancer cells.
Subject(s)
Breast , Breast Neoplasms , Cell Line , Curcuma , Curcumin , Cytokines , Diterpenes, Kaurane , Glucosides , Imidazoles , Medical Oncology , Mitomycin , Molecular Mechanisms of Pharmacological Action , Niacin , Plants , Proteins , Solubility , Transcription Factors , WaterABSTRACT
Objective:To explore the timing and indications of preventive antibiotics-using cholecystectomy.Methods:304 cases of cholecystectomied patients were divided into 4 groups and compared.Results:Compare wound infection rate of preventive group with that of control group,χ2=8.5,P<0.01,with that of group having more infectious chance,χ2=7.1,P<0.01,with that of group having less infectious chance,χ2=0.4,P>0.05.Compare wound infection rate of all patients that have different preventive medicine-using time,χ2=0.02,P>0.05.Conclusion:preventive antibiotics-using in group having more infectious chance can decrease postoperative wound infection rate apparently.Medicine should be used from anesthesia induction period,and using time shouldn't excess 2 days.Of all medicines,gentamicin and metronidazole are preferable medicines to choose.